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Article

CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?

Cell research - 1 Aug 2012

Zhao Yongchao, Sun Yi

Abstract excerpt

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies...

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Identifiers

PMID: 22584258
DOI: 10.1038/cr.2012.79
PMCID: PMC3411174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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