Article
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
PloS one - 1 Jan 2011
Kajiro Masashi, Tsuchiya Mai, Kawabe Yoh-Ichi, Furumai Ryohei, Iwasaki Naoya, Hayashi Yuki, Katano Miyuki, Nakajima Yuka, Goto Natsuka, Watanabe Tatsuya, Murayama Akiko, Oishi Hisashi, Ema Masatsugu, Takahashi Satoru, Kishimoto Hiroyuki, Yanagisawa Junn
Abstract excerpt
Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that ubiquitinates ARF and APP-BP1. However, the significance of Trip12 in vivo is largely unknown. Here we show that the ubiquitin ligase activity of Trip12 is indispensable for mouse embryogenesis. A homozygous mutation in Trip12 (Trip12(mt/mt)) that disrupts...
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