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Article

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.

Molecular cell - 1 Jun 2000

Frank K M, Sharpless N E, Gao Y, Sekiguchi J M, Ferguson D O, Zhu C, Manis J P, Horner J, DePinho R A, Alt F W

Abstract excerpt

DNA ligase IV (LIG4) is a nonhomologous end-joining (NHEJ) protein used for V(D)J recombination and DNA repair. In mice, Lig4 deficiency causes embryonic lethality, massive neuronal apoptosis, arrested lymphogenesis, and various cellular defects. Herein, we assess potential roles in this phenotype for INK4a/ARF and p53, two proteins implicated in apoptosis and senescence. INK4a/ARF deficiency rescued...

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Source

Identifiers

PMID: 10911993
DOI: 10.1016/s1097-2765(00)80264-6

Genes

LIG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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