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Article

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.

Molecular and cellular biology - 1 Jan 2008

Tsutsumi Takeya, Kuwabara Hiroshi, Arai Takehiro, Xiao Yonghong, Decaprio James A

Abstract excerpt

CUL7 binds to SKP1, RBX1, and FBXW8 to form a cullin-RING ligase, or an SKP1-cullin-F box protein complex. The targeted disruption of the Cul7 gene in mice results in significant reduction in embryo size and neonatal lethality. In humans, CUL7 was found to be mutated in the 3-M dwarfism syndrome characterized by severe pre- and postnatal growth retardation, indicating that CUL7 is closely associated with human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17998335
DOI: 10.1128/MCB.01665-07
PMCID: PMC2223430

Genes

CUL7
SKP1
IGFBP1
IGFBP2
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.PMID 17998335Read ↗

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