Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.

doi:10.7554/eLife.50346

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.

eLife - 5 May 2021

Dinh Tra Thi Huong, Iseki Hiroyoshi, Mizuno Seiya, Iijima-Mizuno Saori, Tanimoto Yoko, Daitoku Yoko, Kato Kanako, Hamada Yuko, Hasan Ammar Shaker Hamed, Suzuki Hayate, Murata Kazuya, Muratani Masafumi, Ema Masatsugu, Kim Jun-Dal, Ishida Junji, Fukamizu Akiyoshi, Kato Mitsuyasu, Takahashi Satoru, Yagami Ken-Ichi, Wilson Valerie, Arkell Ruth M, Sugiyama Fumihiro

Abstract excerpt

In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic lethality in mice. Comparative transcriptome analysis revealed disruption of Cables2, 50% down-regulation of Rps21...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrulation

Share to Gene Expression

Share to Mice, Inbred ICR

Share to Ribosomal Proteins

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 33949947
DOI: 10.7554/eLife.50346
PMCID: PMC8099427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.PMID 33949947Read ↗

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.Semantic proximity Read ↗

Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects.Semantic proximity Read ↗

Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.Semantic proximity Read ↗

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.Semantic proximity Read ↗

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisSemantic proximity Read ↗

CAP2 in cardiac conduction, sudden cardiac death and eye development.Semantic proximity Read ↗

BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.Semantic proximity Read ↗

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.Semantic proximity Read ↗

Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.Semantic proximity Read ↗

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placentaSemantic proximity Read ↗

TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.