Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.

Abstract excerpt

The sequential timing of cell-cycle transitions is primarily governed by the availability and activity of key cell-cycle proteins. Recent studies in yeast have identified a class of ubiquitin ligases (E3 enzymes) called SCF complexes, which regulate the abundance of proteins that promote and inhibit cell-cycle progression at the G1-S phase transition. SCF complexes consist of three invariable components, Skp1,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Death
• Share to Cullin Proteins
• Share to Cyclin E