Article
Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.
The Journal of biological chemistry - 27 Nov 2009
Zou Yongxin, Mi Jun, Cui Jinpeng, Lu Defen, Zhang Xiyu, Guo Chenhong, Gao Guimin, Liu Qiji, Chen Bingxi, Shao Changshun, Gong Yaoqin
Abstract excerpt
CUL4A and CUL4B, which are derived from the same ancestor, CUL4, encode scaffold proteins that organize cullin-RING ubiquitin ligase (E3) complexes. Recent genetic studies have shown that germ line mutation in CUL4B can cause mental retardation, short stature, and other abnormalities in humans. C...
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