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Article

Distinct contributions of replication and transcription to mutation rate variation of human genomes.

Genomics, proteomics & bioinformatics - 1 Feb 2012

Cui Peng, Ding Feng, Lin Qiang, Zhang Lingfang, Li Ang, Zhang Zhang, Hu Songnian, Yu Jun

Abstract excerpt

Here, we evaluate the contribution of two major biological processes--DNA replication and transcription--to mutation rate variation in human genomes. Based on analysis of the public human tissue transcriptomics data, high-resolution replicating map of Hela cells and dbSNP data, we present significant correlations between expression breadth, replication time in local regions and SNP density. SNP density of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22449396
DOI: 10.1016/S1672-0229(11)60028-4
PMCID: PMC5054443

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