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Article

Tissue-specific impacts of aging and genetics on gene expression patterns in humans.

Nature communications - 3 Oct 2022

Yamamoto Ryo, Chung Ryan, Vazquez Juan Manuel, Sheng Huanjie, Steinberg Philippa L, Ioannidis Nilah M, Sudmant Peter H

Abstract excerpt

Age is the primary risk factor for many common human diseases. Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans. We show that the predictive power of expression quantitative trait loci is impacted by age in many tissues. Jointly modelling the contributions of age and genetics to transcript level variation we find expression...

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Source

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Identifiers

PMID: 36192477
DOI: 10.1038/s41467-022-33509-0
PMCID: PMC9530233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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