Integrative assessment of chlorine-induced acute lung injury in mice.

doi:10.1165/rcmb.2012-0026OC

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Article

Integrative assessment of chlorine-induced acute lung injury in mice.

American journal of respiratory cell and molecular biology - 1 Aug 2012

Leikauf George D, Pope-Varsalona Hannah, Concel Vincent J, Liu Pengyuan, Bein Kiflai, Berndt Annerose, Martin Timothy M, Ganguly Koustav, Jang An Soo, Brant Kelly A, Dopico Richard A, Upadhyay Swapna, Di Y P Peter, Li Qian, Hu Zhen, Vuga Louis J, Medvedovic Mario, Kaminski Naftali, You Ming, Alexander Danny C, McDunn Jonathan E, Prows Daniel R, Knoell Daren L, Fabisiak James P

Abstract excerpt

The genetic basis for the underlying individual susceptibility to chlorine-induced acute lung injury is unknown. To uncover the genetic basis and pathophysiological processes that could provide additional homeostatic capacities during lung injury, 40 inbred murine strains were exposed to chlorine, and haplotype association mapping was performed. The identified single-nucleotide polymorphism (SNP) associations...

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Identifiers

PMID: 22447970
DOI: 10.1165/rcmb.2012-0026OC
PMCID: PMC3423464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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