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Article

Oxidative damage to lung mitochondrial DNA is a key contributor to the development of chemical lung injury

31 Mar 2025

Abstract excerpt

Humans exposed to chlorine (Cl 2 ) due to industrial accidents or acts of terrorism may develop lung injury culminating to Acute Respiratory Distress syndrome and death from respiratory failure. Early molecular targets of inhaled oxidant gases suitable for pharmacologic modulation have not been established. Because the mitochondrial genome is highly sensitive to oxidant stress, we tested the hypothesis that mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40209617
DOI: 10.1016/j.redox.2025.103624

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