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Functional genomics of oxidant-induced lung injury.

Advances in experimental medicine and biology - 1 Jan 2001

Leikauf G D, McDowell S A, Bachurski C J, Aronow B J, Gammon K, Wesselkamper S C, Hardie W, Wiest J S, Leikauf J E, Korfhagen T R, Prows D R

Abstract excerpt

In summary, acute lung injury is a severe (>40% mortality) respiratory disease associated with numerous precipitating factors. Despite extensive research since its initial description over 30 years ago, questions remain about the basic pathophysiological mechanisms and their relationship to therapeutic strategies. Histopathology reveals surfactant disruption, epithelial perturbation and sepsis, either as...

Topics

Animals
Environmental Exposure
Epidermal Growth Factor
Genetic Predisposition to Disease
Genomics
Humans
Lung Injury
Nickel
Oxidants
Ozone
Polytetrafluoroethylene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait, Heritable

Transforming Growth Factor alpha

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PMID: 11764985
DOI: 10.1007/978-1-4615-0667-6_73

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