Article
Functional genomics of oxidant-induced lung injury.
Advances in experimental medicine and biology - 1 Jan 2001
Leikauf G D, McDowell S A, Bachurski C J, Aronow B J, Gammon K, Wesselkamper S C, Hardie W, Wiest J S, Leikauf J E, Korfhagen T R, Prows D R
Abstract excerpt
In summary, acute lung injury is a severe (>40% mortality) respiratory disease associated with numerous precipitating factors. Despite extensive research since its initial description over 30 years ago, questions remain about the basic pathophysiological mechanisms and their relationship to therapeutic strategies. Histopathology reveals surfactant disruption, epithelial perturbation and sepsis, either as...
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