Article
Genetic determinants of ammonia-induced acute lung injury in mice.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2021
Bein Kiflai, Ganguly Koustav, Martin Timothy M, Concel Vincent J, Brant Kelly A, Di Y P Peter, Upadhyay Swapna, Fabisiak James P, Vuga Louis J, Kaminski Naftali, Kostem Emrah, Eskin Eleazar, Prows Daniel R, Jang Ann-Soo, Leikauf George D
Abstract excerpt
In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was used to help resolve the genetic determinants of ammonia-induced acute lung injury. The encoded proteins were prioritized based on molecular function, nonsynonymous SNP within a functional...
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