Article
Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice.
Research report (Health Effects Institute) - 1 Dec 2001
Leikauf G D, McDowell S A, Wesselkamper S C, Miller C R, Hardie W D, Gammon K, Biswas P P, Korfhagen T R, Bachurski C J, Wiest J S, Willeke K, Bingham E, Leikauf J E, Aronow B J, Prows D R
Abstract excerpt
To begin identifying genes controlling individual susceptibility to particulate matter, responses of inbred mouse strains exposed to nickel sulfate (NiSO4*) were compared with those of mice exposed to ozone (O3) or polytetrafluoroethylene (PTFE). The A strain was sensitive to NiSO4-induced lung injury (quantified by survival time), the C3H/He (C3) strain and several other strains were intermediate in their...
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