Article
Functional genomic assessment of phosgene-induced acute lung injury in mice.
American journal of respiratory cell and molecular biology - 1 Sept 2013
Leikauf George D, Concel Vincent J, Bein Kiflai, Liu Pengyuan, Berndt Annerose, Martin Timothy M, Ganguly Koustav, Jang An Soo, Brant Kelly A, Dopico Richard A, Upadhyay Swapna, Cario Clinton, Di Y P Peter, Vuga Louis J, Kostem Emrah, Eskin Eleazar, You Ming, Kaminski Naftali, Prows Daniel R, Knoell Daren L, Fabisiak James P
Abstract excerpt
In this study, a genetically diverse panel of 43 mouse strains was exposed to phosgene and genome-wide association mapping performed using a high-density single nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was also used to improve the genetic resolution in the identification of genetic determinants of phosgene-induced acute lung injury (ALI). We prioritized the identified genes based on whether...
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