Article
Functional genomics of chlorine-induced acute lung injury in mice.
Proceedings of the American Thoracic Society - 1 Jul 2010
Leikauf George D, Pope-Varsalona Hannah, Concel Vincent J, Liu Pengyuan, Bein Kiflai, Brant Kelly A, Dopico Richard A, Di Y Peter, Jang An-Soo, Dietsch Maggie, Medvedovic Mario, Li Qian, Vuga Louis J, Kaminski Naftali, You Ming, Prows Daniel R
Abstract excerpt
Acute lung injury can be induced indirectly (e.g., sepsis) or directly (e.g., chlorine inhalation). Because treatment is still limited to supportive measures, mortality remains high ( approximately 74,500 deaths/yr). In the past, accidental (railroad derailments) and intentional (Iraq terrorism) chlorine exposures have led to deaths and hospitalizations from acute lung injury. To better understand the molecular...
Topics
- Animals
- Chlorine
- Female
- Gases
- Genetic Predisposition to Disease
- Genomics
- Inhalation Exposure
- Lung
- Lung Diseases
- Mice