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Article

Molecular genetic analysis of the hepatocyte growth factor/MET signaling pathway in pediatric medulloblastoma.

Genes, chromosomes & cancer - 1 Jul 2012

Onvani Sara, Terakawa Yuzo, Smith Christian, Northcott Paul, Taylor Michael, Rutka James

Abstract excerpt

The hepatocyte growth factor (HGF)/MET pathway plays a critical role in the development of the nervous system and has been implicated in medulloblastoma pathogenesis. Recent studies have shown a role for gene amplification of activators of this pathway, as well as silencing of its inhibitors in medulloblastoma pathogenesis. We analyzed exon array data from a cohort of 103 primary medulloblastomas to show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22447520
DOI: 10.1002/gcc.21954

Genes

MET
HGF
SPINT1
SPINT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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