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Article

MET receptor sequence variants R970C and T992I lack transforming capacity.

Cancer research - 1 Aug 2010

Tyner Jeffrey W, Fletcher Luke B, Wang Ellen Q, Yang Wayne F, Rutenberg-Schoenberg Michael L, Beadling Carol, Mori Motomi, Heinrich Michael C, Deininger Michael W, Druker Brian J, Loriaux Marc M

Abstract excerpt

High-throughput sequencing promises to accelerate the discovery of sequence variants, but distinguishing oncogenic mutations from irrelevant "passenger" mutations remains a major challenge. Here we present an analysis of two sequence variants of the MET receptor (hepatocyte growth factor receptor) R970C and T992I (also designated R988C and T1010I). Previous reports indicated that these sequence variants are...

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Identifiers

PMID: 20670955
DOI: 10.1158/0008-5472.CAN-10-0429
PMCID: PMC2913476

Genes

MET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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