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Article

Allelic mutations in noncoding genomic sequences construct novel transcription factor binding sites that promote gene overexpression.

Genes, chromosomes & cancer - 1 Nov 2015

Tian Erming, Børset Magne, Sawyer Jeffrey R, Brede Gaute, Våtsveen Thea K, Hov Håkon, Waage Anders, Barlogie Bart, Shaughnessy John D, Epstein Joshua, Sundan Anders

Abstract excerpt

The growth and survival factor hepatocyte growth factor (HGF) is expressed at high levels in multiple myeloma (MM) cells. We report here that elevated HGF transcription in MM was traced to DNA mutations in the promoter alleles of HGF. Sequence analysis revealed a previously undiscovered single-nu...

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Share to Binding Sites
Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Hepatocyte Growth Factor

Share to Multiple Myeloma

Share to Promoter Regions, Genetic

Share to Transcription Factors

Source

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Identifiers

PMID: 26220195
DOI: 10.1002/gcc.22280
PMCID: PMC5644988

Genes

HGF
MZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26220195-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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