Article
Expression and mutational analysis of MET in human solid cancers.
Genes, chromosomes & cancer - 1 Dec 2008
Ma Patrick C, Tretiakova Maria S, MacKinnon Alexander C, Ramnath Nithya, Johnson Candace, Dietrich Sascha, Seiwert Tanguy, Christensen James G, Jagadeeswaran Ramasamy, Krausz Thomas, Vokes Everett E, Husain Aliya N, Salgia Ravi
Abstract excerpt
MET receptor tyrosine kinase and its ligand hepatocyte growth factor (HGF) regulate a variety of cellular functions, many of which can be dysregulated in human cancers. Activated MET signaling can lead to cell motility and scattering, angiogenesis, proliferation, branching morphogenesis, invasion, and eventual metastasis. We performed systematic analysis of the expression of the MET receptor and its ligand HGF in...
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