Article
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
Cancer research - 15 Jan 1999
Park W S, Dong S M, Kim S Y, Na E Y, Shin M S, Pi J H, Kim B J, Bae J H, Hong Y K, Lee K S, Lee S H, Yoo N J, Jang J J, Pack S, Zhuang Z, Schmidt L, Zbar B, Lee J Y
Abstract excerpt
The MET protooncogene encodes a transmembrane tyrosine kinase identified as the receptor of a polypeptide known as hepatocyte growth factor/scatter factor. We performed PCR-based single-strand conformational polymorphism and sequencing analysis of the tyrosine kinase domain of the MET gene (exon 15-19) in 75 primary liver cancers. Three missense mutations were detected exclusively in 10 childhood hepatocellular...
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