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Article

An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma.

Cancer research - 1 Dec 2008

Kongkham Paul N, Northcott Paul A, Ra Young Shin, Nakahara Yukiko, Mainprize Todd G, Croul Sidney E, Smith Christian A, Taylor Michael D, Rutka James T

Abstract excerpt

Medulloblastoma (MB) is a malignant cerebellar tumor that occurs primarily in children. The hepatocyte growth factor (HGF)/MET pathway has an established role in both normal cerebellar development as well as the development and progression of human brain tumors, including MB. To identify novel tumor suppressor genes involved in MB pathogenesis, we performed an epigenome-wide screen in MB cell lines, using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19047176
DOI: 10.1158/0008-5472.CAN-08-2169

Genes

SPINT2
MET
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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