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Enhanced expression and phosphorylation of the MET oncoprotein by glioma‐specific PTPRZ1–MET fusions

29 Apr 2015

Abstract excerpt

PTPRZ1-MET (ZM) proteins are a group of fusion proteins identified in human gliomas by high-throughput transcriptome sequencing. ZM fusions are associated with poor prognosis in afflicted glioma patients and mediate oncogenic effects in assays. In this study, we show that ZM-carrying patients have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced by fusion with receptor-type...

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PMID: 25935522
DOI: 10.1016/j.febslet.2015.04.032

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