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Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET

1 May 2023

Abstract excerpt

INTRODUCTION: HGF/c-MET signaling is a significant driver of glioblastoma (GBM) growth and disease progression. Unfortunately, c-MET targeted therapies have been found to be largely ineffective suggesting additional redundant mechanisms of c-MET activation. METHODS: Utilizing RNA-sequencing (RNA-seq) and ribosome profiling analyses of circular RNAs, circ-HGF (hsa_circ_0080914) was identified as markedly...

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PMID: 37162666
DOI: 10.1007/s11060-023-04331-5

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