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Article

Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNFVal/Met mice.

Journal of cellular physiology - 1 Oct 2022

Musazzi Laura, Tornese Paolo, Sala Nathalie, Lee Francis S, Popoli Maurizio, Ieraci Alessandro

Abstract excerpt

Stressful life events are considered major risk factors for the development of several psychiatric disorders, though people differentially cope with stress. The reasons for this are still largely unknown but could be accounted for by individual genetic variants, previous life events, or the kind of stressors. The human brain-derived neurotrophic factor (BDNF) Val66Met variant, which was found to impair...

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Identifiers

PMID: 35908196
DOI: 10.1002/jcp.30833
PMCID: PMC9796250

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