Article
Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide.
Journal of translational medicine - 22 Mar 2012
Duarte Julio D, Zineh Issam, Burkley Ben, Gong Yan, Langaee Taimour Y, Turner Stephen T, Chapman Arlene B, Boerwinkle Eric, Gums John G, Cooper-Dehoff Rhonda M, Beitelshees Amber L, Bailey Kent R, Fillingim Roger B, Kone Bruce C, Johnson Julie A
Abstract excerpt
BACKGROUND: Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal epithelial sodium channel (ENaC) provides a mechanism for fine-tuning sodium excretion, and is a major regulator of blood pressure homeostasis. DOT1L, MLLT3, SIRT1, and SGK1 encode genes in a...
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