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Article

Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation.

BMC molecular biology - 22 Mar 2012

Abdel-Hafiz Hany A, Horwitz Kathryn B

Abstract excerpt

BACKGROUND: Covalent modification of nuclear receptors by the Small Ubiquitin-like Modifier (SUMO) is dynamically regulated by competing conjugation/deconjugation steps that modulate their overall transcriptional activity. SUMO conjugation of progesterone receptors (PRs) at the N-terminal lysine (K) 388 residue of PR-B is hormone-dependent and suppresses PR-dependent transcription. Mutation of the SUMOylation...

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Identifiers

PMID: 22439847
DOI: 10.1186/1471-2199-13-10
PMCID: PMC3373386

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SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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