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Article

Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007

Daniel Andrea R, Faivre Emily J, Lange Carol A

Abstract excerpt

Progesterone receptors (PRs) mediate proliferation during breast development and contribute to breast cancer progression, in part by synergizing with peptide growth factors. We have previously identified PR Ser294 as a key site for direct regulation of PR location, activity, and turnover in response to phosphorylation events. Herein, we sought to better understand how hormonal cross talk alters PR function. We...

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PMID: 17717077
DOI: 10.1210/me.2007-0248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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