Article
SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
Molecular biology of the cell - 1 Apr 2006
Tiefenbach Jens, Novac Natalia, Ducasse Miryam, Eck Maresa, Melchior Frauke, Heinzel Thorsten
Abstract excerpt
In the absence of ligands the corepressor N-CoR mediates transcriptional repression by some nuclear hormone receptors. Several protein-protein interactions of N-CoR are known, of which mainly complex formation with histone deacetylases (HDACs) leads to the repression of target genes. On the other hand, the role of posttranslational modifications in corepressor function is not well established. Here, we show that...
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