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Article

Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling.

PloS one - 1 Jan 2014

Lee Wai-Ping, Jena Sarita, Doherty Declan, Ventakesh Jaganathan, Schimdt Joachim, Furmick Julie, Widener Tim, Lemau Jana, Jurutka Peter W, Thompson Paul D

Abstract excerpt

Vitamin D receptor (VDR) is a substrate for modification with small ubiquitin-like modifier (SUMO). To further assess the role of reversible SUMOylation within the vitamin D hormonal response, we evaluated the effects of sentrin/SUMO-specific proteases (SENPs) that can function to remove small ubiquitin-like modifier (SUMO) from target proteins upon the activities of VDR and related receptors. We report that...

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Source

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Identifiers

PMID: 24586832
DOI: 10.1371/journal.pone.0089506
PMCID: PMC3930751

Genes

VDR
SENP1
SENP2
SUMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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