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Article

SUMOylation of RORalpha potentiates transcriptional activation function.

Biochemical and biophysical research communications - 16 Jan 2009

Hwang Eun Ju, Lee Ji Min, Jeong Jiyeong, Park Joo Hyeon, Yang Young, Lim Jong-Seok, Kim Jung Hwa, Baek Sung Hee, Kim Keun Il

Abstract excerpt

SUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, RORalpha by both SUMO-1 and SUMO-2. SUMOylation of RORalpha occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASxalpha, PIAS3, and PIASy, increased SUMOylation of RORalpha, whereas SENP2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Receptor Subfamily 1, Group F, Member 1

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Source

Identifiers

PMID: 19041634
DOI: 10.1016/j.bbrc.2008.11.072

Genes

PIAS3
SENP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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