Article
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
PLoS genetics - 1 Jan 2012
Olszewski Pawel K, Rozman Jan, Jacobsson Josefin A, Rathkolb Birgit, Strömberg Siv, Hans Wolfgang, Klockars Anica, Alsiö Johan, Risérus Ulf, Becker Lore, Hölter Sabine M, Elvert Ralf, Ehrhardt Nicole, Gailus-Durner Valérie, Fuchs Helmut, Fredriksson Robert, Wolf Eckhard, Klopstock Thomas, Wurst Wolfgang, Levine Allen S, Marcus Claude, de Angelis Martin Hrabě, Klingenspor Martin, Schiöth Helgi B, Kilimann Manfred W
Abstract excerpt
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice...
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