Article
The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2012
Buchner David A, Geisinger Jon M, Glazebrook Patricia A, Morgan Michael G, Spiezio Sabrina H, Kaiyala Karl J, Schwartz Michael W, Sakurai Takeshi, Furley Andrew J, Kunze Diana L, Croniger Colleen M, Nadeau Joseph H
Abstract excerpt
Despite considerable effort, the identification of genes that regulate complex multigenic traits such as obesity has proven difficult with conventional methodologies. The use of a chromosome substitution strain-based mapping strategy based on deep congenic analysis overcame many of the difficulties associated with gene discovery and led to the finding that the juxtaparanodal proteins CNTNAP2 and TAG1 regulate...
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