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Article

Extreme obesity is associated with variation in genes related to the circadian rhythm of food intake and hypothalamic signaling.

Physiological genomics - 1 Jun 2015

Mariman Edwin C M, Bouwman Freek G, Aller Erik E J G, van Baak Marleen A, Wang Ping

Abstract excerpt

The hypothalamus is important for regulation of energy intake. Mutations in genes involved in the function of the hypothalamus can lead to early-onset severe obesity. To look further into this, we have followed a strategy that allowed us to identify rare and common gene variants as candidates for the background of extreme obesity from a relatively small cohort. For that we focused on subjects with a well-selected...

Read the complete abstract on PubMed

Topics

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Share to Circadian Rhythm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Hypothalamus

Share to INDEL Mutation

Share to Obesity, Morbid

Share to Signal Transduction

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Source

Identifiers

PMID: 25805767
DOI: 10.1152/physiolgenomics.00006.2015

Genes

BAIAP3
LEPR
MBOAT4
NBEA
NPC1
NPW
NUCB2
PER1
RYR1
SIM1
TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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