Article
Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype.
PloS one - 1 Jan 2012
Lee Angela W S, Hengstler Heidi, Schwald Kathrin, Berriel-Diaz Mauricio, Loreth Desirée, Kirsch Matthias, Kretz Oliver, Haas Carola A, de Angelis Martin Hrabě, Herzig Stephan, Brümmendorf Thomas, Klingenspor Martin, Rathjen Fritz G, Rozman Jan, Nicholson George, Cox Roger D, Schäfer Michael K E
Abstract excerpt
To date, genome-wide association studies (GWAS) have identified at least 32 novel loci for obesity and body mass-related traits. However, the causal genetic variant and molecular mechanisms of specific susceptibility genes in relation to obesity are yet to be fully confirmed and characterised. Here, we examined whether the candidate gene NEGR1 encoding the neuronal growth regulator 1, also termed neurotractin or...
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