Article
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation.
Molecular psychiatry - 1 May 2025
Giuranna Johanna, Zheng Yiran, Brandt Matthäus, Jall Sigrid, Mukherjee Amrita, Shankhwar Soni, Renner Simone, Kurapati Nirup Kumar, May Caroline, Peters Triinu, Herpertz-Dahlmann Beate, Seitz Jochen, de Zwaan Martina, Herzog Wolfgang, Ehrlich Stefan, Zipfel Stephan, Giel Katrin, Egberts Karin, Burghardt Roland, Föcker Manuel, Marcus Katrin, Keyvani Kathy, Müller Timo D, Schmitz Frank, Rajcsanyi Luisa Sophie, Hinney Anke
Abstract excerpt
The C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did a mutation analysis in CTBP2 by performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant for AN and body weight regulation and ensued...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Animals
- Adolescent