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Article

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.

PLoS pathogens - 1 Jan 2012

Walther Michael, De Caul Adam, Aka Peter, Njie Madi, Amambua-Ngwa Alfred, Walther Brigitte, Predazzi Irene M, Cunnington Aubrey, Deininger Susanne, Takem Ebako N, Ebonyi Augustine, Weis Sebastian, Walton Robert, Rowland-Jones Sarah, Sirugo Giorgio, Williams Scott M, Conway David J

Abstract excerpt

Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression. In many diseases including murine malaria, HO-1 induction produces protective anti-inflammatory effects, but observations from patients suggest these may be limited to a narrow range of HO-1...

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Identifiers

PMID: 22438807
DOI: 10.1371/journal.ppat.1002579
PMCID: PMC3305414

Genes

HMOX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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