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Article

HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset.

Malaria journal - 17 Nov 2022

Hamilton Fergus, Mitchell Ruth, Cunnington Aubrey, Ghazal Peter, Timpson Nicholas J

Abstract excerpt

BACKGROUND: Inducible expression of heme oxygenase-1 (encoded by the gene HMOX1) may determine protection from heme released during malaria infections. A variable length, short tandem GT(n) repeat (STR) in HMOX1 that may influence gene expression has been associated with outcomes of human malaria in some studies. In this study, an analysis of the association between variation at the STR in HMOX1 on severe malaria...

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Identifiers

PMID: 36397106
DOI: 10.1186/s12936-022-04352-x
PMCID: PMC9670449

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