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Article

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease.

Blood - 1 Nov 2012

Bean Christopher J, Boulet Sheree L, Ellingsen Dorothy, Pyle Meredith E, Barron-Casella Emily A, Casella James F, Payne Amanda B, Driggers Jennifer, Trau Heidi A, Yang Genyan, Jones Kimberly, Ofori-Acquah Solomon F, Hooper W Craig, DeBaun Michael R

Abstract excerpt

Sickle cell disease is a common hemolytic disorder with a broad range of complications, including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme oxygenase-1 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might attenuate the severity of outcomes from vaso-occlusive and hemolytic crises. A (GT)(n) dinucleotide repeat located in the...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multiplex Polymerase Chain Reaction

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Source

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Identifiers

PMID: 22966170
DOI: 10.1182/blood-2011-06-361642
PMCID: PMC3488892

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease.PMID 22966170Read ↗

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