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Article

Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection.

Clinical and experimental immunology - 1 May 2017

Ademolue T W, Amodu O K, Awandare G A

Abstract excerpt

The controlled induction of haemoxygenase-1 (HO-1), an enzyme that catabolizes haem, has been shown to reduce haem, preventing pathologies associated with haem toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a longitudinal approach, we investigated the effect of baseline concentrations of HO-1 on the...

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Identifiers

PMID: 28142190
DOI: 10.1111/cei.12936
PMCID: PMC5383446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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