Article
Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria.
Infection and immunity - 1 Apr 2012
Mendonça Vitor R R, Luz Nívea F, Santos Nadja J G, Borges Valéria M, Gonçalves Marilda S, Andrade Bruno B, Barral-Netto Manoel
Abstract excerpt
Intravascular hemolysis is a hallmark event in the immunopathology of malaria that results in increased systemic concentrations of free hemoglobin (Hb). The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation. To circumvent the detrimental effects of free heme, hosts have developed several homeostatic mechanisms, including the enzyme haptoglobin (Hp), which scavenges...
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