Article
The HIV cytopathic effect: potential target for therapy?
Journal of acquired immune deficiency syndromes - 1 Jan 1990
Bremermann H J, Anderson R W
Abstract excerpt
HIV kills activated infected CD4+ T cells after a burst of replication and the release of large numbers of virions. From a review of the literature on HIV regulatory genes and from preliminary mathematical models of HIV dynamics at four levels (host population epidemiology, the immune system, gene regulation within infected cells, and selection of mutants) we have arrived at the theory that in the etiology of HIV...
Topics
- CD4 Antigens
- Cytopathogenic Effect, Viral
- Disease Models, Animal
- Genes, Regulator
- Genes, Viral
- HIV
- HIV Infections
- Humans
- Models, Biological
- Mutation
- T-Lymphocytes