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Article

Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.

Immunity - 1 Feb 2003

Bobbitt Kevin R, Addo Marylyn M, Altfeld Marcus, Filzen Tracey, Onafuwa Adewunmi A, Walker Bruce D, Collins Kathleen L

Abstract excerpt

The HIV Nef protein is thought to promote HIV immune evasion by downmodulating MHC-I and protecting infected cells from CTL killing. In addition, we demonstrated that Rev, an HIV regulatory protein needed for expression of the HIV late genes, can influence CTL killing. When Rev activity level was reduced by virtue of amino acid alterations in the Rev protein sequence, infected cells were more resistant to...

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Identifiers

PMID: 12594955
DOI: 10.1016/s1074-7613(03)00031-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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