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Article

Evidence for a cytopathogenicity determinant in HIV-1 Vpr.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002

Somasundaran Mohan, Sharkey Mark, Brichacek Beda, Luzuriaga Katherine, Emerman Michael, Sullivan John L, Stevenson Mario

Abstract excerpt

HIV-1 is cytopathic for CD4(+) T lymphocytes in vitro and this property of HIV-1 is generally considered to account for some of its in vivo cytopathogenicity. Thus, the extent of lymphocyte depletion correlates with the level of viremia whereas low levels of viral replication are typically associated with stable lymphocyte levels and asymptomatic infection such as is observed in non-progressors. Here, we describe...

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Share to CD4-Positive T-Lymphocytes
Share to Cytopathogenic Effect, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, vpr

Share to HIV Infections

Share to HIV Long-Term Survivors

Share to In Vitro Techniques

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 12093916
DOI: 10.1073/pnas.142313699
PMCID: PMC123170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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