Article
A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America - 26 Apr 1994
Smythe J A, Sun D, Thomson M, Markham P D, Reitz M S, Gallo R C, Lisziewicz J
Abstract excerpt
One strategy for somatic gene therapy for human immunodeficiency virus type 1 (HIV-1) infection is based on the regulated expression of dominant negative mutants of the HIV-1 gag gene. To limit expression of the mutant Gag polypeptide to HIV-1-infected cells, we have constructed a replication-defective retroviral vector that contains a Rev-responsive element. By using this construct we have obviated problems that...
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