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Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr

1 Sept 1995

Abstract excerpt

We investigated the fate of human immunodeficiency virus type 1 (HIV-1) viral DNA in infected peripheral blood lymphocytes and immortalized T-cell lines by using a replication-defective HIV-1. We observed that integrated HIV-1 DNA and viral gene expression decrease over time. A frameshift mutation in vpr resulted in maintenance of the HIV-1 provirus and stable persistence of viral expression. Transfection of vpr...

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PMID: 7637036
DOI: 10.1128/jvi.69.9.5883-5889.1995

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