Vpr Cytopathicity Independent of G 2 /M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4 + T Cells

Abstract excerpt

The mechanism of CD4(+) T-cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected individuals remains unknown, although mounting evidence suggests that direct viral cytopathicity contributes to this loss. The HIV-1 Vpr accessory protein causes cell death and arrests cells in the G(2)/M phase; however, the molecular mechanism underlying these properties is not clear. Mutation of hydrophobic residues...

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