Article
Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
Neurobiology of disease - 1 Jul 2012
Hernandez Dena G, Nalls Mike A, Moore Matthew, Chong Sean, Dillman Allissa, Trabzuni Daniah, Gibbs J Raphael, Ryten Mina, Arepalli Sampath, Weale Michael E, Zonderman Alan B, Troncoso Juan, O'Brien Richard, Walker Robert, Smith Colin, Bandinelli Stefania, Traynor Bryan J, Hardy John, Singleton Andrew B, Cookson Mark R
Abstract excerpt
Genome-wide association studies have nominated many genetic variants for common human traits, including diseases, but in many cases the underlying biological reason for a trait association is unknown. Subsets of genetic polymorphisms show a statistical association with transcript expression levels, and have therefore been nominated as expression quantitative trait loci (eQTL). However, many tissue and cell types...
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