Article
Tissue-specific genetic control of splicing: implications for the study of complex traits.
PLoS biology - 23 Dec 2008
Heinzen Erin L, Ge Dongliang, Cronin Kenneth D, Maia Jessica M, Shianna Kevin V, Gabriel Willow N, Welsh-Bohmer Kathleen A, Hulette Christine M, Denny Thomas N, Goldstein David B
Abstract excerpt
Numerous genome-wide screens for polymorphisms that influence gene expression have provided key insights into the genetic control of transcription. Despite this work, the relevance of specific polymorphisms to in vivo expression and splicing remains unclear. We carried out the first genome-wide screen, to our knowledge, for SNPs that associate with alternative splicing and gene expression in human primary cells,...
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