Article
Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.
Molecular and cellular biology - 1 May 2012
He Zhao, Zhang Sharon S, Meng Qingyuan, Li Shuangwei, Zhu Helen H, Raquil Marie-Astrid, Alderson Nazilla, Zhang Hai, Wu Jiarui, Rui Liangyou, Cai Dongsheng, Feng Gen-Sheng
Abstract excerpt
In mammals, leptin regulates food intake and energy balance mainly through the activation of LepRb in the hypothalamus, and estrogen has a leptin-like effect in the hypothalamic control of metabolism. However, it remains to be elucidated how estrogen signaling is intertwined with the leptin pathway. We show here that Shp2, a nonreceptor tyrosine phosphatase, acts to integrate leptin and estrogen signals. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.